[IGoudt]

I would make use of a variable 'audioPlaying = True/False' that's being checked everytime a key-event occurs.

snippets: (I use self here since I think in classes/objects)

def playAudio(self, file):
self.audioPlaying = True
..code to start audio

def onkeydown(self, key):
if not self.audioPlaying:
 ... handle keys
else:
     print "audio playing, so keys are disabled"

in the place where you register onkeydown, register the following:

viz.callback(viz.MEDIA_END, self.audioEnded)

def audioEnded(self, e):
     self.audioPlaying = False